GENETIC DISSECTION OF DIFFERENTIAL SIGNALING THRESHOLD REQUIREMENTS FOR THE WNT/BETA-CATENIN PATHWAY IN VIVO.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes.To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele combinations Bumpers by genetically restricting intracellular beta-catenin expression in the cor

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Real-World Effectiveness, Treatment Pattern, and Safety of Ranibizumab in Korean Patients with Neovascular Age-Related Macular Degeneration: Subgroup Analyses from the LUMINOUS Study

Min Sagong,1 Se Joon Woo,2 Youkyung Lee3 On behalf of the LUMINOUS™ study investigators from South Korea1Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea; 2Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea; 3Novartis Korea Ltd., Seoul, KoreaCorrespondence: Se Joon WooDep

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Raman Microscopy: Progress in Research on Cancer Cell Sensing

In the last decade, Raman Spectroscopy (RS) was demonstrated to be a label-free, non-invasive and non-destructive optical spectroscopy allowing the improvement in diagnostic accuracy in cancer and analytical assessment for cell sensing.This review discusses how Raman spectra can lead to a deeper molecular understanding of the biochemical changes in

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Propulsion Aspects of Unmanned and Manned Lunar Landings

Direct vertical descent and descent from an intermediate<br />lunar parking orbit are discussed.The difference in philosophy between<br />langing a payload of instruments and of humans is considered in some<br />detail.The " Storage Solution human return to eartli " problem is separated from the<br />" mission success-failur

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