Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes.To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele combinations Bumpers by genetically restricting intracellular beta-catenin expression in the cor